ABSTRACT
OBJECTIVE: To determine the impact of periodontal treatment on serum levels of prohepcidin (the prohormone of hepcidin) and systemic inflammation markers, as well as correlations among these markers, in patients with chronic periodontitis and chronic kidney disease who were not undergoing dialysis. METHODS: We included 56 chronic periodontitis patients, 36 with chronic kidney disease and 20 without systemic diseases and with normal renal function (control group). Chronic kidney disease was defined as suggested by the clinical practice guidelines in the National Kidney Foundation. Chronic periodontitis was defined through clinical attachment level and by probing pocket depth, according to the American Association of Periodontology. The inflammatory markers ultrasensitive C-reactive protein, interleukin-6, and prohepcidin were evaluated before and 3 months after periodontal treatment. RESULTS: The efficacy of periodontal treatment was confirmed by the improvement in clinical parameters of chronic periodontitis in the control and chronic kidney disease groups. Periodontal treatment resulted in significant reductions in ultrasensitive C-reactive protein, interleukin-6 and serum prohepcidin levels in both groups. Moreover, in multivariate linear regression, the reduction in prohepcidin after periodontal treatment was significantly and independently associated with interleukin-6 levels in the control group. CONCLUSIONS: By inducing a decline in the systemic inflammatory response and a decrease in serum prohepcidin, successful periodontal treatment may represent an important means of ameliorating the inflammatory burden seen in patients with chronic kidney disease.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Antimicrobial Cationic Peptides/blood , Chronic Periodontitis/therapy , Kidney Failure, Chronic/blood , Protein Precursors/blood , Subgingival Curettage/adverse effects , Biomarkers/blood , C-Reactive Protein/analysis , Chronic Periodontitis/diagnosis , Inflammation/blood , /blood , Treatment OutcomeABSTRACT
En este trabajo se trata, en una forma simple y esquemática, de recordar que pequeños actos quirúrgicos, en determinados pacientes, sea en la cavidad bucal o en otras partes del organismo, son capaces de producir bacteriemia con consecuencias graves para el enfermo. Además, se señala cuáles son los principales factores de riesgo de la endocarditis bacteriana, los microorganismos más comunes causantes de lamisma, las maniobras que inducen a bacteriemias y, tomando en cuenta las últimas publicaciones, mostrar un esquema terapéutico actualizado en la prevención de la endocarditis